VS-15

Cat. No.: HY-168092: FAQs
Data Sheet Handling Instructions

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VS-15, a IDO1 inhibitor, selectively binds the heme-free form of IDO1. VS-15 is described as an iNOS inhibitor based on the reduction of NO production.

For research use only. We do not sell to patients.

VS-15 Chemical Structure

CAS No. : 951948-78-0

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IDO1 IDO2 IDO

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nNOS iNOS eNOS

Biological Activity
Purity & Documentation
References
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Description	VS-15, a IDO1 inhibitor, selectively binds the heme-free form of IDO1. VS-15 is described as an iNOS inhibitor based on the reduction of NO production^[1].
In Vitro	VS-15 reduces the IDO1-mediated signaling pathway by negatively interfering with its partnership with SHPs and PI3K regulatory subunit p85 as well as with the IDO1 anchoring to the early endosomes in tumor cells^[1]. VS-15 counteracts the TGF-β-mediated immunosuppressive phenotype in dendritic cells and reduces the level of inhibition of T cell proliferation by suppressive monocytes isolated from patients affected by pancreatic cancer^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. VS-15 Related Antibodies
Molecular Weight	493.56
Formula	C₂₉H₂₇N₅O₃
CAS No.	951948-78-0
SMILES	O=C(NCCC1=CNC2=C1C=CC=C2)C3=C(NC(C(NCCC4=CNC5=C4C=CC=C5)=O)=O)C=CC=C3
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (267 KB) Handling Instructions (2659 KB)
References	[1]. Eleonora Panfili, et al. Identification of a Compound Inhibiting Both the Enzymatic and Nonenzymatic Functions of Indoleamine 2,3-Dioxygenase 1. ACS Pharmacol Transl Sci. 2024 Sep 12;7(10):3056-3070. [Content Brief]

VS-15 Related Classifications

Inflammation/Immunology

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VS-15951948-78-0VS15VS 15Indoleamine 2,3-Dioxygenase (IDO)NO SynthaseNitric oxide synthasesNOSInhibitorinhibitorinhibit

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