VTSEGAGLQLQK-¹³C₆,¹⁵N₂ TFA 

VTSEGAGLQLQK-¹³C₆,¹⁵N₂ (TFA) is the ¹³C- and ¹⁵N-labeled VTSEGAGLQLQK. VTSEGAGLQLQK is an amino acid sequence in the C-terminal region of recombinant human alpha-acid glucosidase (rhGAA), which can be used to bind anti-drug antibodies in plasma and quantitatively analyze the therapeutic effect^[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1238.31 (free acid)

C₄₆¹³C₆H₉₁N₁₃¹⁵N₂O₁₉.xC₂HF₃O₂

Val-Thr-Ser-Glu-Gly-Ala-Gly-Leu-Gln-Leu-Gln-{Lys-13C6,15N2} (TFA salt)

VTSEGAGLQLQ-{Lys-13C6,15N2} (TFA salt)

O=C(C(F)(F)F)O.O=C([C@@H](N)C(C)C)N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C([15NH][13C@H]([13C](O)=O)[13CH2][13CH2][13CH2][13CH2][15NH2])=O)CCC(N)=O)=O)CC(C)C)=O)CCC(N)=O)=O)CC(C)C)=O)=O)C)=O)=O)CCC(O)=O)=O)CO)=O)[C@@H](C)O.[x]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bronsema KJ, et al. Absolute quantification of the total and antidrug antibody-bound concentrations of recombinant human α-glucosidase in human plasma using protein G extraction and LC-MS/MS. Anal Chem. 2015 Apr 21;87(8):4394-401.  [Content Brief]