VTSEGAGLQLQK-¹³C₆,¹⁵N₂

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VTSEGAGLQLQK-¹³C₆,¹⁵N₂ is the ¹³C and ¹⁵N labeled VTSEGAGLQLQK. VTSEGAGLQLQK is an amino acid sequence in the C-terminal region of recombinant human alpha-acid glucosidase (rhGAA). VTSEGAGLQLQK can be used to bind anti-drug antibodies (ADA) in plasma and quantitatively analyze the therapeutic effect.

For research use only. We do not sell to patients.

VTSEGAGLQLQK-<sup>13</sup>C<sub>6</sub>,<sup>15</sup>N<sub>2</sub> Chemical Structure

VTSEGAGLQLQK-¹³C₆,¹⁵N₂ Chemical Structure

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1 mg		Get quote	Estimated Time of Arrival: December 31

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Other Forms of VTSEGAGLQLQK-¹³C₆,¹⁵N₂:

VTSEGAGLQLQK-¹³C₆,¹⁵N₂ TFA Get quote

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Description	VTSEGAGLQLQK-¹³C₆,¹⁵N₂ is the ¹³C and ¹⁵N labeled VTSEGAGLQLQK. VTSEGAGLQLQK is an amino acid sequence in the C-terminal region of recombinant human alpha-acid glucosidase (rhGAA). VTSEGAGLQLQK can be used to bind anti-drug antibodies (ADA) in plasma and quantitatively analyze the therapeutic effect^[1]^[2].
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. VTSEGAGLQLQK-¹³C₆,¹⁵N₂ Related Antibodies
Molecular Weight	1238.31
Formula	C₄₆¹³C₆H₉₁N₁₃¹⁵N₂O₁₉
SMILES	O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](C)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C([15NH][13C@@H]([13CH2][13CH2][13CH2][13CH2][15NH2])[13C](O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C(C)C)N
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-217. [Content Brief] [2]. Bronsema KJ, et al. Absolute quantification of the total and antidrug antibody-bound concentrations of recombinant human α-glucosidase in human plasma using protein G extraction and LC-MS/MS. Anal Chem. 2015 Apr 21;87(8):4394-401. [Content Brief]