VU0038882

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VU0038882 is a small-molecule activator of coproporphyrinogen oxidase (CgoX). VU0038882 can activate CgoX from Gram-Positive bacteria in vitro. VU0038882 can be used for the research of skin and soft tissue infections (SSTIs) .

For research use only. We do not sell to patients.

VU0038882 Chemical Structure

CAS No. : 429653-28-1

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Description	VU0038882 is a small-molecule activator of coproporphyrinogen oxidase (CgoX). VU0038882 can activate CgoX from Gram-Positive bacteria in vitro. VU0038882 can be used for the research of skin and soft tissue infections (SSTIs) ^[1].
In Vitro	VU0038882 (‘882) (40 μM) exposure leads to accumulation of CPIII in S. aureus^[1]. VU0038882 (0-10 μM) activates CgoX from Gram-Positive bacteria in vitro^[1]. VU0038882 (50 μM) induces photosensitivity in Gram-positive pathogens^[1]. VU0038882 leads to massive heme accumulation resulting in HssRS activation in S. aureus^[1]. VU0038882 leads to photosensitization of Gram-positive bacteria, reducing bacterial burdens in vivo^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. VU0038882 Related Antibodies
Molecular Weight	276.29
Formula	C₁₇H₁₂N₂O₂
CAS No.	429653-28-1
SMILES	OC1=C2C=CC=CC2=CC=C1C3=NNC(C4=CC=CO4)=C3
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Mao Y, et al. Development of a MMAE-based antibody-drug conjugate targeting B7-H3 for glioblastoma. Eur J Med Chem. 2023;257:115489. [Content Brief]

VU0038882 Related Classifications

Infection

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU0038882429653-28-1VU 0038882VU-0038882Bacterialcoproporphyrinogen oxidase (CgoX)Gram-Positive bacteriaskinsoft tissue infections (SSTIs)Inhibitorinhibitorinhibit

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VU0038882

VU0038882 Related Antibodies

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