VU0400195  (Synonyms: ML182)

VU0400195 (ML182) is a oral active and allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4) with the EC₅₀ of 291 nM. VU0400195 can be used for study of antiparkinsonian animal model^[1][2].

393.82

C₂₁H₁₆ClN₃O₃

1309434-83-0

O=C(C1=NC=CC=C1)NC2=CC=C(C(Cl)=C2)N3C([C@@]4([C@@]5([H])C[C@@]([H])([C@]4([H])C3=O)C=C5)[H])=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jones CK, et al. Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal model. J Med Chem. 2011 Nov 10;54(21):7639-47.  [Content Brief]

  [2]. Darren W. Engers, et al. Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4). ACS Chem. Neurosci. 2016, 7, 9, 1192–1200.