2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. VU0546110

VU0546110 is a selective inhibitor of the sperm-specific potassium channel SLO3, with IC50s of 1.287 μM (SLO3) and 59.80 μM (SLO1) in HEK293 cells, respectively. VU0546110 blocks heterologous SLO3 currents and endogenous K+ currents in human sperm. VU0546110 halts sperm hyperpolarization, induced acrosome reaction, and hyper-activated motility. VU0546110 has contraceptive potential.

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VU0546110 Chemical Structure

VU0546110 Chemical Structure

CAS No. : 1421523-00-3

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VU0546110 Related Antibodies

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Description

VU0546110 is a selective inhibitor of the sperm-specific potassium channel SLO3, with IC50s of 1.287 μM (SLO3) and 59.80 μM (SLO1) in HEK293 cells, respectively. VU0546110 blocks heterologous SLO3 currents and endogenous K+ currents in human sperm. VU0546110 halts sperm hyperpolarization, induced acrosome reaction, and hyper-activated motility. VU0546110 has contraceptive potential[1].

IC50 & Target

1.287 μM (SLO3), 59.80 μM (SLO1)[1]
In Vitro

VU0546110 (10 μM) blocks the K+ current in human sperm at intracellular free Ca2+ concentrations of 0-50 µM[1].
VU0546110 (2.5 μM) inhibits the hyperpolarized membrane potential at pH 8.0 in human spermatozoa[1].
VU0546110 (2.5-10 μM) inhibits the hyperactivated motility and Ca2+ ionophore A23187 (HY-N6687) or progesterone (HY-N0437) induced acrosome reaction in human sperm[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VU0546110 Related Antibodies
Molecular Weight

461.64

Formula

C24H31NO4S2
CAS No.
SMILES

O=C(CC1=CC=C(S(=O)(C(C)C)=O)C=C1)N2CCC(CC2)CSC3=CC=C(C=C3)OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VU0546110 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU05461101421523-00-3VU 0546110VU-0546110Potassium ChannelKcsASpermHyperpolarizationFertilizationHEK293 CellsAcrosome reactionInhibitorinhibitorinhibit

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