2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. VUF 8430 dihydrobromide

VUF 8430 (dihydrobromide) is a potent and selective histamine H4 receptor agonist with a Ki of 31.6 nM and an EC50 of 50 nM.

For research use only. We do not sell to patients.

VUF 8430 dihydrobromide Chemical Structure

VUF 8430 dihydrobromide Chemical Structure

CAS No. : 100130-32-3

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5 mg USD 232 In-stock
10 mg USD 370 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of VUF 8430 dihydrobromide:

VUF 8430 dihydrobromide Related Antibodies

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

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Description

VUF 8430 (dihydrobromide) is a potent and selective histamine H4 receptor agonist with a Ki of 31.6 nM and an EC50 of 50 nM[1].

IC50 & Target

H4 receptor

 

Molecular Weight

323.05

Formula

C4H13Br2N5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N=C(N)SCCNC(N)=N.[H]Br.[H]Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (386.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0955 mL 15.4775 mL 30.9550 mL
5 mM 0.6191 mL 3.0955 mL 6.1910 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.0955 mL 15.4775 mL 30.9550 mL 77.3874 mL
5 mM 0.6191 mL 3.0955 mL 6.1910 mL 15.4775 mL
10 mM 0.3095 mL 1.5477 mL 3.0955 mL 7.7387 mL
15 mM 0.2064 mL 1.0318 mL 2.0637 mL 5.1592 mL
20 mM 0.1548 mL 0.7739 mL 1.5477 mL 3.8694 mL
25 mM 0.1238 mL 0.6191 mL 1.2382 mL 3.0955 mL
30 mM 0.1032 mL 0.5159 mL 1.0318 mL 2.5796 mL
40 mM 0.0774 mL 0.3869 mL 0.7739 mL 1.9347 mL
50 mM 0.0619 mL 0.3095 mL 0.6191 mL 1.5477 mL
60 mM 0.0516 mL 0.2580 mL 0.5159 mL 1.2898 mL
80 mM 0.0387 mL 0.1935 mL 0.3869 mL 0.9673 mL
100 mM 0.0310 mL 0.1548 mL 0.3095 mL 0.7739 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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VUF 8430 dihydrobromide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VUF 8430 dihydrobromide100130-32-3Histamine ReceptorSK-N-MC cellsInhibitorinhibitorinhibit

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