2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. VUF10132

VUF10132 is a non-peptide CXCR3 receptor antagonist with anti-inflammatory activity, inhibiting diseases such as rheumatoid arthritis, multiple sclerosis, and psoriasis. VUF10132 has high affinity for the human CXCR3 receptor but slightly lower affinity for the murine CXCR3 receptor. Additionally, VUF10132 exhibits inverse agonist properties at the CXCR3 receptor.

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VUF10132 Chemical Structure

VUF10132 Chemical Structure

CAS No. : 1037732-88-9

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VUF10132 Related Antibodies

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Description

VUF10132 is a non-peptide CXCR3 receptor antagonist with anti-inflammatory activity, inhibiting diseases such as rheumatoid arthritis, multiple sclerosis, and psoriasis. VUF10132 has high affinity for the human CXCR3 receptor but slightly lower affinity for the murine CXCR3 receptor. Additionally, VUF10132 exhibits inverse agonist properties at the CXCR3 receptor[1].

IC50 & Target

CXCR3[1]
Molecular Weight

523.03

Formula

C19H13BrCl4N2O2
CAS No.
SMILES

O=C(CN1C=[N+](C=C1)CC(C2=CC=C(C(Cl)=C2)Cl)=O)C3=CC=C(C(Cl)=C3)Cl.[Br-]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VUF10132 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VUF101321037732-88-9VUF 10132VUF-10132CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsInhibitorinhibitorinhibit

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