2. Apoptosis
  3. Apoptosis
  4. Waltonitone

Waltonitone is a ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill. Waltonitone significantly inhibits hepatocellular carcinoma cells growth and induces apoptosis in vitro and in vivo.

For research use only. We do not sell to patients.

Waltonitone Chemical Structure

Waltonitone Chemical Structure

CAS No. : 1252676-55-3

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Based on 1 publication(s) in Google Scholar

Waltonitone Related Antibodies

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Description

Waltonitone is a ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill. Waltonitone significantly inhibits hepatocellular carcinoma cells growth and induces apoptosis in vitro and in vivo[1].

In Vitro

waltonitone (10 μM, 25 μM; for 48 hours) results in an increment of sub-G1 population in BEL-7402 cells[1].
Waltonitone (25 μM; for 48 hours) induces BEL-7402 cells apoptosis[1].
Waltonitone (25 μM; for 48 hours) can effectively activate caspase-3 in BEL-7402 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Waltonitone Related Antibodies
In Vivo

Waltonitone (i.v.; 20 mg/kg or 50 mg/kg; once every two days for 16 days) inhibits BEL-7402 tumor growth in male athymic mice (BALB/c nu/nu) in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

440.70

Formula

C30H48O2
CAS No.
SMILES

CC1(C)C(CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@](CO)5CC[C@](C)4[C@@](C)3CC[C@@]12[H])=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Waltonitone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Waltonitone1252676-55-3Apoptosisursane-typepentacyclictriterpeneGentianwaltoniiBurkillhepatocellularcarcinomaInhibitorinhibitorinhibit

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