WDR5-MYC-IN-1

Cat. No.: HY-163774: FAQs
Data Sheet Handling Instructions

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WDR5-MYC-IN-1 (compound 4o) is a potent WDR5-MYC interaction inhibitor with a Ki value of 1.0 µM. WDR5-MYC-IN-1 shows antiproliferative activity.

For research use only. We do not sell to patients.

WDR5-MYC-IN-1 Chemical Structure

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View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms

EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

Biological Activity
Purity & Documentation
References
Customer Review

Description

WDR5-MYC-IN-1 (compound 4o) is a potent WDR5-MYC interaction inhibitor with a Ki value of 1.0 µM. WDR5-MYC-IN-1 shows antiproliferative activity^[1].

IC₅₀ & Target

K_i: 1.0 µM (WDR5-MYC)^[1]

In Vitro

WDR5-MYC-IN-1 (compound 4o) shows antiproliferative activity with IC₅₀s of 1.52, 1.51, 2.20, 5.32, 7.40 µM for RAJI, RAMOS, SUDHL4, HL-60, H1299 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	RAJI, RAMOS, SUDHL4, HL-60, H1299 cells
Concentration:
Incubation Time:
Result:	Showed antiproliferative activity with IC₅₀s of 1.52, 1.51, 2.20, 5.32, 7.40 µM for RAJI, RAMOS, SUDHL4, HL-60, H1299 cells, respectively.

Molecular Weight

290.36

Formula

C₁₂H₁₀N₄OS₂

SMILES

O=C(NC)C1=CC=C(C2=C(SC#N)SC(N)=N2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang H, et al. Identification of 5-Thiocyanatothiazol-2-amines Disrupting WDR5-MYC Protein-Protein Interactions. ACS Med Chem Lett. 2024 Jul 1;15(7):1143-1150. [Content Brief]

WDR5-MYC-IN-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WDR5-MYC-IN-1Histone MethyltransferaseantiproliferativecancerInhibitorinhibitorinhibit

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