2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. WNK-IN-11-d3

WNK-IN-11-d3 is an orally active, selective and potent With-No-Lysine (WNK) kinase inhibitor. WNK-IN-11-d3 is effective at regulating cardiovascular homeostasis[1].

For research use only. We do not sell to patients.

WNK-IN-11-d<sub>3</sub> Chemical Structure

WNK-IN-11-d3 Chemical Structure

CAS No. : 2123483-49-6

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Based on 1 publication(s) in Google Scholar

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WNK-IN-11-d3 Related Antibodies

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Description

WNK-IN-11-d3 is an orally active, selective and potent With-No-Lysine (WNK) kinase inhibitor. WNK-IN-11-d3 is effective at regulating cardiovascular homeostasis[1].

IC50 & Target

WNK[1]
In Vivo

WNK-IN-11 D3 (1.5 mg/kg; p.o.) shows an improved rat PK profile, including lower clearance, improvement in absolute oral exposure, and a 2-fold improvement in oral bioavailability[1].
WNK-IN-11 D3 (30 mg/kg; p.o.) shows significant reductions in systolic blood pressure (SBP) vs untreated mice[1].
WNK-IN-11 D3 (0~100 mg/kg; p.o.) induces dose dependent diuresis, natriuresis, and kaliuresis, from 10 to 100 mg/kg[1].
WNK-IN-11 D3 shows trends toward reduction of blood pressure, stroke volume, and total peripheral resistance, while increasing heart rate. WNK-IN-11 D3 shows efficacy in rodent models of hypertension and volume overload[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague−Dawley rats[1]
Dosage: 1.5 mg/kg
Administration: P.o.
Result: Showed an improved rat PK profile, including lower clearance, improvement in absolute oral exposure, and a 2-fold improvement in oral bioavailability.
Animal Model: FVB mice[1]
Dosage: 30 mg/kg
Administration: P.o.
Result: Showed significant reductions in systolic blood pressure (SBP) vs untreated mice.
Animal Model: FVB mice[1]
Dosage: 0~100 mg/kg
Administration: P.o.
Result: Induced dose dependent diuresis, natriuresis, and kaliuresis, from 10 to 100 mg/kg.
Molecular Weight

465.41

Formula

C21H18D3Cl2N5OS
CAS No.
Unlabeled CAS

2123489-30-3
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N1CCN(CC1)CC2=CC=C(C=C2)Cl)C3=CC(C4=CSC(NC([2H])([2H])[2H])=N4)=NC=C3Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (214.86 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 100 mg/mL (214.86 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1486 mL 10.7432 mL 21.4864 mL
5 mM 0.4297 mL 2.1486 mL 4.2973 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.84%

SDS (251 KB)

COA (246 KB) HNMR (134 KB) RP-HPLC (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 2.1486 mL 10.7432 mL 21.4864 mL 53.7161 mL
5 mM 0.4297 mL 2.1486 mL 4.2973 mL 10.7432 mL
10 mM 0.2149 mL 1.0743 mL 2.1486 mL 5.3716 mL
15 mM 0.1432 mL 0.7162 mL 1.4324 mL 3.5811 mL
20 mM 0.1074 mL 0.5372 mL 1.0743 mL 2.6858 mL
25 mM 0.0859 mL 0.4297 mL 0.8595 mL 2.1486 mL
30 mM 0.0716 mL 0.3581 mL 0.7162 mL 1.7905 mL
40 mM 0.0537 mL 0.2686 mL 0.5372 mL 1.3429 mL
50 mM 0.0430 mL 0.2149 mL 0.4297 mL 1.0743 mL
60 mM 0.0358 mL 0.1791 mL 0.3581 mL 0.8953 mL
80 mM 0.0269 mL 0.1343 mL 0.2686 mL 0.6715 mL
100 mM 0.0215 mL 0.1074 mL 0.2149 mL 0.5372 mL
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WNK-IN-11-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WNK-IN-11-d32123483-49-6Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesorallyactiveselectivepotenteffectivecardiovascularhomeostasisInhibitorinhibitorinhibit

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