2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. STAT Bcl-2 Family
  4. WR-S-462

WR-S-462 is a STAT3 inhibitor. WR-S-462 effectively suppresses STAT3 phosphorylation and biological functions in vitro. WR-S-462 inhibits MDA-MB-231 cells with an IC50 of 0.03 μM. WR-S-462 displays a strong binding affinity towards the STAT3 protein with a Kd of 58 nM. WR-S-462 inhibits the nuclear translocation of p-STAT3, selectively inhibits the expression of p-STAT3Tyr705 and downstream target genes regulated by STAT3 in MDA-MB-231 cells such as Cyclin D1, Bcl-2, and Bcl-xl. WR-S-462 inhibits TNBC (triple-negative breast cancer) growth and metastasis.

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WR-S-462 Chemical Structure

WR-S-462 Chemical Structure

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WR-S-462 Related Antibodies

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Description

WR-S-462 is a STAT3 inhibitor. WR-S-462 effectively suppresses STAT3 phosphorylation and biological functions in vitro. WR-S-462 inhibits MDA-MB-231 cells with an IC50 of 0.03 μM. WR-S-462 displays a strong binding affinity towards the STAT3 protein with a Kd of 58 nM. WR-S-462 inhibits the nuclear translocation of p-STAT3, selectively inhibits the expression of p-STAT3Tyr705 and downstream target genes regulated by STAT3 in MDA-MB-231 cells such as Cyclin D1, Bcl-2, and Bcl-xl. WR-S-462 inhibits TNBC (triple-negative breast cancer) growth and metastasis[1].

IC50 & Target[1]

STAT3

58 nM (Kd)

Bcl-2

 

BCLxL

 

Molecular Weight

462.52

Formula

C24H22N4O4S
SMILES

COC1=C(NC(N2CC(SC(NC(C3=CC=CC(OC)=C3)=O)=C4C#N)=C4CC2)=O)C=CC=C1
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Purity & Documentation
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WR-S-462 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WR-S-462STATBcl-2 Familytriple-negative breast cancerphosphorylationgrowthmetastasisMDA-MB-231 cellsInhibitorinhibitorinhibit

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