2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. WRN inhibitor 10

WRN inhibitor 10 (Compound P24) is an inhibitor for the Werner helicase WRN with an IC50 of 1.1 nM. WRN inhibitor 10 inhibits the proliferation of cancer cell SW48 with IC50 of 39 nM. WRN inhibitor 10 exhibits good liver microsomal stability and film permeability. WRN inhibitor 10 exhibits good pharmacokinetic characteristics in CD-1 mice.

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WRN inhibitor 10 Chemical Structure

WRN inhibitor 10 Chemical Structure

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Description

WRN inhibitor 10 (Compound P24) is an inhibitor for the Werner helicase WRN with an IC50 of 1.1 nM. WRN inhibitor 10 inhibits the proliferation of cancer cell SW48 with IC50 of 39 nM. WRN inhibitor 10 exhibits good liver microsomal stability and film permeability. WRN inhibitor 10 exhibits good pharmacokinetic characteristics in CD-1 mice[1].

Molecular Weight

755.04

Formula

C31H29BrClN9O5S
SMILES

O=C(N1CCN(CC1)C2=C(N(C3=NC(C4=CC5=C(S4)COC5)=NN3C2=O)CC(NC6=CC=C(C=C6Cl)Br)=O)CC)C7=NC=NC(C)=C7O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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WRN inhibitor 10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WRN inhibitor 10WRN inhibitor10WRN inhibitor-10DNA/RNA Synthesiscolorectal cancerSW48MSI-HHT-29CD-1 mouseInhibitorinhibitorinhibit

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