WRN inhibitor 6 

WRN inhibitor 6 (compound 3ci) is a potent WRN inhibitor. WRN inhibitor 6 induces apoptosis. WRN inhibitor 6 increases the expression of p-p53, P-Chk2, γH2AX expression^[1].

IC₅₀:2.305 µM (WRN)^[1]

WRN inhibitor 6 (compound 3ci) (0-100 µM; 72 h) induces DNA damage and apoptotic cell death with IC₅₀s of 2.305, 16.58 µM for HCT116, SW620 cells, respectively^[1].
WRN inhibitor 6 (0, 2.5, 5, 10 µM; 3, 27 h) increases the expression of p-p53, P-Chk2, γH2AX expression in a dose-dependent manner in HCT116 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

WRN inhibitor 6 (20 mg/kg for p.o.; 5 mg/kg for i.v.) shows low oral availability with F of 11.43% and a short half-life of 0.17 h for IV in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

494.64

C₂₉H₃₄O₅S

CCOC1=CC=C(C=C1)C2=CC=C(S2)C(C3=C(CC(C)(CC3=O)C)O)C4=C(CC(C)(CC4=O)C)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yang H, et al. Discovery of thiophen-2-ylmethylene bis-dimedone derivatives as novel WRN inhibitors for treating cancers with microsatellite instability. Bioorg Med Chem. 2024 Feb 15;100:117588.  [Content Brief]