2. PI3K/Akt/mTOR Apoptosis
  3. PI3K Apoptosis
  4. XJTU-L453

XJTU-L453 is a PI3Kα inhibitor with an IC50 value of 0.4 nM. XJTU-L453 can inhibit the proliferation of breast cancer cell lines T47D and MCF7, with IC50 values of 0.2 μM and 0.5 μM, respectively. XJTU-L453 can inhibit the PI3K pathway, induce cell cycle arrest, and trigger cell apoptosis (apoptosis). XJTU-L453 also has antitumor activity in MCF7 xenograft mice.

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XJTU-L453 Chemical Structure

XJTU-L453 Chemical Structure

CAS No. : 3008290-92-1

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XJTU-L453 Related Antibodies

Top Publications Citing Use of Products

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Description

XJTU-L453 is a PI3Kα inhibitor with an IC50 value of 0.4 nM. XJTU-L453 can inhibit the proliferation of breast cancer cell lines T47D and MCF7, with IC50 values of 0.2 μM and 0.5 μM, respectively. XJTU-L453 can inhibit the PI3K pathway, induce cell cycle arrest, and trigger cell apoptosis (apoptosis). XJTU-L453 also has antitumor activity in MCF7 xenograft mice[1].
IC50 & Target

PI3Kα

 

Molecular Weight

390.44

Formula

C22H22N4O3
CAS No.
SMILES

NC([C@@H](OC1=CC(OCC2=C3C=C(C4=NC=NC(NCC)=C4)C=C2)=C3C=C1)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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XJTU-L453 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XJTU-L4533008290-92-1PI3KApoptosisPhosphoinositide 3-kinasePI3Kαbreast cancerapoptosisInhibitorinhibitorinhibit

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