2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. XP5

XP5 is a potent, orally active HDAC6 inhibitor with an IC50 of 31 nM. XP5 displays high antiproliferative activity against various cancer cell lines including the HDACi-resistant YCC3/7 gastric cancer cells (IC50=0.16-2.31 μM). XP5 enhances antitumor immunity when combined with a PD-L1 inhibitor in melanoma.

For research use only. We do not sell to patients.

XP5 Chemical Structure

XP5 Chemical Structure

CAS No. : 2760511-91-7

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XP5 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

XP5 is a potent, orally active HDAC6 inhibitor with an IC50 of 31 nM. XP5 displays high antiproliferative activity against various cancer cell lines including the HDACi-resistant YCC3/7 gastric cancer cells (IC50=0.16-2.31 μM). XP5 enhances antitumor immunity when combined with a PD-L1 inhibitor in melanoma[1].

Molecular Weight

407.48

Formula

C19H25N3O5S
CAS No.
SMILES

COC1=CC=C(C(OC)=C1)C2=NC=C(S2)C(NCCCCCCC(NO)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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XP5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XP52760511-91-7XP 5XP-5HDACHistone deacetylasesoralantiproliferativegastric cancer cellsantitumor immunityInhibitorinhibitorinhibit

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