2. Cell Cycle/DNA Damage
  3. CDK
  4. Xylocydine

Xylocydine is an inhibitor of CDK1/2, inhibiting CDK function in various apoptotic processes. Xylocydine specifically blocks CDK1 and CDK2 activity with IC50 of 1.4 nM and 61 nM, respectively. In addition, Xylocydine downregulates phosphorylated nucleolin and retinoblastoma protein levels..

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Xylocydine Chemical Structure

Xylocydine Chemical Structure

CAS No. : 685901-63-7

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Xylocydine Related Antibodies

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Description

Xylocydine is an inhibitor of CDK1/2, inhibiting CDK function in various apoptotic processes. Xylocydine specifically blocks CDK1 and CDK2 activity with IC50 of 1.4 nM and 61 nM, respectively. In addition, Xylocydine downregulates phosphorylated nucleolin and retinoblastoma protein levels.[1].

IC50 & Target

IC50: 1.4 nM (CDK1), 61 nM (CDK2)[1]
Cellular Effect
Cell Line Type Value Description References
HeLa IC50
0.0014 μM
Compound: 2
Inhibition of CDK1/Cyclin B in human HeLa cell extracts using histone H1 as substrate preincubated for 30 mins before substrate addition measured after 15 mins by autoradiography
Inhibition of CDK1/Cyclin B in human HeLa cell extracts using histone H1 as substrate preincubated for 30 mins before substrate addition measured after 15 mins by autoradiography
[PMID: 22036212]
HeLa IC50
0.061 μM
Compound: 2
Inhibition of CDK2/Cyclin A2 in human HeLa cell extracts using histone H1 as substrate preincubated for 30 mins before substrate addition measured after 15 mins by autoradiography
Inhibition of CDK2/Cyclin A2 in human HeLa cell extracts using histone H1 as substrate preincubated for 30 mins before substrate addition measured after 15 mins by autoradiography
[PMID: 22036212]
Molecular Weight

388.17

Formula

C12H14BrN5O5
CAS No.
SMILES

O=C(N)C1=C(N([C@H]2O[C@@H](CO)[C@@H](O)[C@@H]2O)C3=NC=NC(N)=C31)Br
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Purity & Documentation
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Xylocydine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xylocydine685901-63-7CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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