Y08284

Cat. No.: HY-142772: FAQs
Data Sheet Handling Instructions

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Y08284 is a potent, selective, oral active CBP bromodomain inhibitor with an IC50 of 4.21 nM. Y08284 suppresses the proliferation of prostate cancer cell lines LNCaP, C4-2B, and 22Rv1. Antitumor activity.

For research use only. We do not sell to patients.

Y08284 Chemical Structure

CAS No. : 2688745-47-1

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
CWR22R	IC₅₀	2.04 μM Compound: 9g; Y08284	Antiproliferative activity against human 22Rv1 cells assessed as cell growth inhibition by Celltiter-Glo assay Antiproliferative activity against human 22Rv1 cells assessed as cell growth inhibition by Celltiter-Glo assay	[PMID: 34962793]
LNCaP	IC₅₀	0.59 μM Compound: 9g; Y08284	Antiproliferative activity against human LNCaP cells assessed as cell growth inhibition by Celltiter-Glo assay Antiproliferative activity against human LNCaP cells assessed as cell growth inhibition by Celltiter-Glo assay	[PMID: 34962793]
LNCaP C4-2B	IC₅₀	6.43 μM Compound: 9g; Y08284	Antiproliferative activity against human LNCaP C4-2B cells assessed as inhibition of cell growth by Celltiter-Glo assay Antiproliferative activity against human LNCaP C4-2B cells assessed as inhibition of cell growth by Celltiter-Glo assay	[PMID: 34962793]

In Vivo

Y08284 demonstrates favorable cell permeability and good pharmacokinetic properties, with oral bioavailability of 25.9%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

476.50

Formula

C₂₆H₂₅FN₄O₄

CAS No.

2688745-47-1

SMILES

O=C(C1=C2C=C(OC)C=CN2C(C(C)=O)=C1)NC3=CC(C(O)C)=CC(C4=CN(C5CC5)N=C4)=C3F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xiang Q, et al. Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer. J Med Chem. 2022;65(1):785-810. [Content Brief]

Y08284 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Y082842688745-47-1Y 08284Y-08284Epigenetic Reader Domaincell permeabilityoral bioavailabilityCBP Bromodomainproliferationprostate cancerInhibitorinhibitorinhibit

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