YAP/TAZ-TEAD-IN-2

Cat. No.: HY-168704: FAQs
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YAP/TAZ-TEAD-IN-2 (Compound 51) is a YAP/TAZ-TEAD inhibitor that inhibits the interaction between YAP/TAZ and TEAD. YAP/TAZ-TEAD-IN-2 suppresses the transcriptional activity of TEAD, with an IC₅₀ of 1.2 nM. YAP/TAZ-TEAD-IN-2 inhibits YAP/TAZ-TEAD target genes expression (Cyr61, CTGF, AXL and Survivin) and breast cancer cell proliferation.

For research use only. We do not sell to patients.

YAP/TAZ-TEAD-IN-2 Chemical Structure

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Description

In Vitro

YAP/TAZ-TEAD-IN-2 (2.5-20 μM, 72 h) dose-dependently inhibits MDA-MB-231 cells proliferation with IC₅₀ of 4.4 μM^[1].
YAP/TAZ-TEAD-IN-2 (1-10 μM, 48 h) inhibits the expression of four major YAP/TAZ-TEAD target proteins, i.e., Cyr61, CTGF, AXL and BIRC5 (Survivin) in MDA-MB-231 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	MDA-MB-231 cells
Concentration:	2.5, 5, 10, 20 μM
Incubation Time:	72 h
Result:	Dose-dependently inhibited MDA-MB-231 cells proliferation with IC₅₀ of 4.4 μM.

Cell Proliferation Assay^[1]

Cell Line:	MDA-MB-231 cells
Concentration:	1, 5, 10 μM
Incubation Time:	48 h
Result:	Dose-dependently inhibited the four principal YAP/TAZ-TEAD target proteins, namely Cyr61, CTGF, AXL and BIRC5 (Survivin).

Molecular Weight

356.44

Formula

C₁₉H₂₀N₂O₃S

SMILES

O=S(NCCN(C=C1)C(C1=C2)=CC=C2OCC3=CC=CC=C3)(C=C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Toulotte, et al. Towards the design of ligands of the internal pocket TEADs C-terminal domain. European journal of medicinal chemistry, 2025, 282, 117026.

YAP/TAZ-TEAD-IN-2 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YAP/TAZ-TEAD-IN-2YAPTAM ReceptorSurvivinYes-associated proteinTyro3AxlMerBreast cancerProliferationMDA-MB-231 cellsHippoCyr61Inhibitorinhibitorinhibit

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