2. Metabolic Enzyme/Protease
  3. Aminoacyl-tRNA Synthetase
  4. YH16899

YH16899 binds Lysyl-tRNA synthetase (KRS), and inhibits membrane translocation of KRS. YH16899 impares the interaction of KRS with 67LR. YH16899 inhibits tumor metastasis in mouse models.

For research use only. We do not sell to patients.

YH16899 Chemical Structure

YH16899 Chemical Structure

CAS No. : 1428623-14-6

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YH16899 Related Antibodies

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Description

YH16899 binds Lysyl-tRNA synthetase (KRS), and inhibits membrane translocation of KRS. YH16899 impares the interaction of KRS with 67LR. YH16899 inhibits tumor metastasis in mouse models[1].

Cellular Effect
Cell Line Type Value Description References
NCI-H226 EC50
8.5 μM
Compound: YH16899
Antimigratory activity against human NCI-H226 cells assessed as inhibition of cell migration measured after 12 hrs by Transwell assay
Antimigratory activity against human NCI-H226 cells assessed as inhibition of cell migration measured after 12 hrs by Transwell assay
[PMID: 33831781]
Molecular Weight

444.38

Formula

C19H13F5N2O3S
CAS No.
SMILES

O=C(C1=CC=CC(C(F)(F)F)=C1)/N=C2N(C(CC)C(O)=O)C3=CC(F)=C(F)C=C3S/2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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YH16899 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YH168991428623-14-6YH 16899YH-16899Aminoacyl-tRNA SynthetasetRNA Synthetase, aaRSKRS67LRtumor metastasisH226 cellsWI-26 cellInhibitorinhibitorinhibit

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