2. Neuronal Signaling
  3. Amyloid-β
  4. YIAD-0205

YIAD-0205 is an orally available Aβ(1?42) aggregation inhibitor. YIAD-0205 demonstrated in vivo efficacy in an AD transgenic mouse model with five familial AD mutations (5XFAD).

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YIAD-0205 Chemical Structure

YIAD-0205 Chemical Structure

CAS No. : 2446054-34-6

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YIAD-0205 Related Antibodies

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Description

YIAD-0205 is an orally available Aβ(1?42) aggregation inhibitor. YIAD-0205 demonstrated in vivo efficacy in an AD transgenic mouse model with five familial AD mutations (5XFAD)[1].

In Vitro

YIAD-0205（10 μM, 100 μM） inhibits Aβ(1?42) aggregation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

YIAD-0205 Related Antibodies
In Vivo

YIAD-0205 (50 mg/kg; po; two times per week for one month) reduces the level of Aβ plaques and Aβ oligomers in 6.0-month-old 5XFAD mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

565.69

Formula

C26H16Br2ClN3
CAS No.
SMILES

BrC1=C(Br)C=C(N(C(C2=CC=CC=C2)=C(CC3=CC=C(Cl)C=C3)N4C5=CC=C4)C5=N6)C6=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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YIAD-0205 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YIAD-02052446054-34-6YIAD0205YIAD 0205Amyloid-ββ-amyloid peptideAβAbetaAlzheimer’s disease (AD)aggregate dissociatorsaggregation inhibitorsamyloid-β (Aβ)drug candidate scaffoldsmall moleculesInhibitorinhibitorinhibit

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HY-149430
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