YL93 

YL93 is a dual inhibitors of MDM2/4 with K_i values of 0.64 μM and 1.1 nM for MDM4 and MDM2, respectively. YL93 induces cell-cycle arrest and apoptosis. YL93 shows p53-dependent cell growth inhibition^[1].

YL93 shows anti-tumor activity and inhibits HCT-116 cell growth with an IC₅₀ value of 50.7 nM^[1].
YL93 (0.078-2.5 μM; 24 h) increases the protein level of p53, p21, MDM2^[1].
YL93 (0.02-2.5 μM; 24 h) arrests cell cycle at G1^[1].
YL93 (6.25-25 μM; 48 h) increases apoptotic RKO cells^[1].
YL93 (2.5 μM; 48 h) increases transcription of p53-targeted genes, MDM2, p21, and PUMA in MDM4-overexpressing cell lines H460, MCF-7, and U-2 OS^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

711.62

C₃₇H₃₈Cl₂F₂N₄O₄

2771313-42-7

FC(C(Cl)=CC=C1)=C1[C@@H]([C@@H](N[C@H]2CC(C)(C)C)C(NC3=CC=C(C=C3OC)C(O)=O)=O)[C@]2(C4=CC=C(Cl)C=C4F)CNCC5=CC=NC=C5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhang S, et al. Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells. J Med Chem. 2022 Apr 28;65(8):6207-6230.  [Content Brief]