2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. YM-202074 fumarate

YM-202074 fumarate is a selective, allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist with high affinity and neuroprotective properties in vivo. YM-202074 fumarate binds to the allosteric site of rat mGluR1 with a Ki value of 4.8 nM. YM-202074 fumarate also inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 value of 8.6 nM. YM-202074 fumarate can be used in stroke research.

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YM-202074 fumarate Chemical Structure

YM-202074 fumarate Chemical Structure

CAS No. : 299900-84-8

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YM-202074 fumarate Related Antibodies

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Description

YM-202074 fumarate is a selective, allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist with high affinity and neuroprotective properties in vivo. YM-202074 fumarate binds to the allosteric site of rat mGluR1 with a Ki value of 4.8 nM. YM-202074 fumarate also inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 value of 8.6 nM. YM-202074 fumarate can be used in stroke research[1].

IC50 & Target[1]

rat mGluR1

4.8 nM (Ki)

Molecular Weight

1177.34

Formula

C56H72N8O16S2
CAS No.
SMILES

OC(/C=C/C(O)=O)=O.CN(C1CCCCC1)C(C2=CN3C4=CC(CN(C)CCOC)=CC=C4N=C3S2)=O.OC(/C=C/C(O)=O)=O.OC(/C=C/C(O)=O)=O.CN(C5CCCCC5)C(C6=CN7C8=CC(CN(C)CCOC)=CC=C8N=C7S6)=O
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Purity & Documentation
References
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YM-202074 fumarate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YM-202074299900-84-8YM202074YM 202074mGluRMetabotropic glutamate receptorsAntagonistsneuroprotective effectscerebellar granulosa cellsstrokeInhibitorinhibitorinhibit

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