2. Immunology/Inflammation
  3. NOD-like Receptor (NLR) Interleukin Related
  4. YM-I-26

YM-I-26 is a selective NLRP3 inflammasome inhibitor. YM-I-26 enhances the phagocytosis of β-amyloid protein by mouse microglial BV2 cells and inhibits the production of IL-1β and IL-10. YM-I-26 can be used to study the immunomodulatory activity associated with inflammation.

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YM-I-26 Chemical Structure

YM-I-26 Chemical Structure

CAS No. : 2585015-90-1

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YM-I-26 Related Antibodies

Top Publications Citing Use of Products

View All NOD-like Receptor (NLR) Isoform Specific Products:

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NLRP3 NLRP1 NOD1 NOD2

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

YM-I-26 is a selective NLRP3 inflammasome inhibitor. YM-I-26 enhances the phagocytosis of β-amyloid protein by mouse microglial BV2 cells and inhibits the production of IL-1β and IL-10. YM-I-26 can be used to study the immunomodulatory activity associated with inflammation[1].

IC50 & Target

IL-1β

 

IL-10

 

Molecular Weight

577.16

Formula

C28H33ClN2O5S2
CAS No.
SMILES

O=S(C1=CC=C(CCN(CC2=C(OCCC)C=CC(Cl)=C2)C(CC3=CSC=C3)=O)C=C1)(N4CCOCC4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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YM-I-26 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YM-I-262585015-90-1NOD-like Receptor (NLR)Interleukin RelatedILSelectiveInflammasomeInhibitorBV2 cellsAmyloidImmunomodulationinhibitorinhibit

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