YM218 free base

Cat. No.: HY-118918: FAQs
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YM218 free base is an orally active non-peptide vasopressin (AVP) receptor antagonist. YM218 free base has a high affinity for rat liver V1A receptors with a K_i value of 0.50 nM; it has a lower affinity for rat pituitary V1B, kidney V2, and uterine oxytocin receptors with K_i values of 1510 nM, 72.2 nM, and 150 nM, respectively. YM218 free base can be used in the study of diabetes and kidney disease.

For research use only. We do not sell to patients.

YM218 free base Chemical Structure

CAS No. : 387816-81-1

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V1a Receptor V1b Receptor V2 Receptor

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Purity & Documentation
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Description

IC₅₀ & Target^[1]

Rat liver V1a Receptor

0.5 nM (Ki)

Rat pituitary V1b receptor

1510 nM (Ki)

Rat kidney V2 receptor

72.2 nM (Ki)

Molecular Weight

616.70

Formula

C₃₅H₃₈F₂N₄O₄

CAS No.

387816-81-1

SMILES

O=C(NC1=CC=C(C=C1)C(N2CCC(F)(/C(C3=CC=CC=C32)=C\C(N4CCC(CC4)N5CCCCC5)=O)F)=O)C6=C(OC=C6)C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tsukada J, et al. Pharmacologic properties of YM218, a novel, potent, nonpeptide vasopressin V1A receptor-selective antagonist[J]. Vascular pharmacology, 2005, 42(2): 47-55. [Content Brief]

YM218 free base Related Classifications

Endocrinology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YM218387816-81-1YM 218YM-218Vasopressin ReceptorVasopressinantagonistselectiveoxytocindiabetesnephropathyorally activeInhibitorinhibitorinhibit

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