2. GPCR/G Protein
  3. Vasopressin Receptor
  4. YM218 free base

YM218 free base is an orally active non-peptide vasopressin (AVP) receptor antagonist. YM218 free base has a high affinity for rat liver V1A receptors with a Ki value of 0.50 nM; it has a lower affinity for rat pituitary V1B, kidney V2, and uterine oxytocin receptors with Ki values of 1510 nM, 72.2 nM, and 150 nM, respectively. YM218 free base can be used in the study of diabetes and kidney disease.

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YM218 free base Chemical Structure

YM218 free base Chemical Structure

CAS No. : 387816-81-1

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YM218 free base Related Antibodies

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Description

YM218 free base is an orally active non-peptide vasopressin (AVP) receptor antagonist. YM218 free base has a high affinity for rat liver V1A receptors with a Ki value of 0.50 nM; it has a lower affinity for rat pituitary V1B, kidney V2, and uterine oxytocin receptors with Ki values of 1510 nM, 72.2 nM, and 150 nM, respectively. YM218 free base can be used in the study of diabetes and kidney disease[1].

IC50 & Target[1]

Rat liver V1a Receptor

0.5 nM (Ki)

Rat pituitary V1b receptor

1510 nM (Ki)

Rat kidney V2 receptor

72.2 nM (Ki)

Molecular Weight

616.70

Formula

C35H38F2N4O4
CAS No.
SMILES

O=C(NC1=CC=C(C=C1)C(N2CCC(F)(/C(C3=CC=CC=C32)=C\C(N4CCC(CC4)N5CCCCC5)=O)F)=O)C6=C(OC=C6)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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YM218 free base Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YM218387816-81-1YM 218YM-218Vasopressin ReceptorVasopressinantagonistselectiveoxytocindiabetesnephropathyorally activeInhibitorinhibitorinhibit

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YM218 free base
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