YM440

Cat. No.: HY-117597: FAQs
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YM440 is an orally active oxadiazolidinedione analog. YM440 ameliorates hyperglycemia without changing PPARy activity, adipocyte differentiation, or fat weight. YM440 is used in the study for non-insulin-dependent diabetes mellitus (NIDDM).

For research use only. We do not sell to patients.

YM440 Chemical Structure

CAS No. : 163300-58-1

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Description	YM440 is an orally active oxadiazolidinedione analog. YM440 ameliorates hyperglycemia without changing PPARy activity, adipocyte differentiation, or fat weight. YM440 is used in the study for non-insulin-dependent diabetes mellitus (NIDDM)^[1].
In Vivo	YM440 (100 mg/kg, orally, daily for 28 days, db/db mice) increases hepatic glucokinase expression but not adipose tissue FABP and UCP1 expression, indicating a tissue selective expression of PPARγ-related genes^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	468.42
Formula	C₂₂H₂₀N₄O₈
CAS No.	163300-58-1
SMILES	O=C(NC1=O)ON1CC2=CC=C(C=C2)OC/C=C\COC3=CC=C(C=C3)CN4OC(NC4=O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (271 KB) Handling Instructions (2659 KB)
References	[1]. A Shimaya, et al. The novel hypoglycemic agent YM440 normalizes hyperglycemia without changing body fat weight in diabetic db/db mice. Metabolism. 2000 Mar;49(3):411-7. [Content Brief] [2]. Eiji Kurosaki, et al. Differential effects of YM440 a hypoglycemic agent on binding to a peroxisome proliferator-activated receptor gamma and its transactivation. Biochem Pharmacol. 2003 Mar 1;65(5):795-805. [Content Brief]

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Metabolic Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YM440163300-58-1YM 440YM-440PPARPeroxisome proliferator-activated receptorsInhibitorinhibitorinhibit

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YM440

YM440 Related Antibodies

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