2. Neuronal Signaling Stem Cell/Wnt
  3. Notch γ-secretase
  4. YO-01027

YO-01027 (Dibenzazepine) (GMP) is YO-01027 (HY-13526) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. YO-01027 is a potent γ-secretase inhibitor.

For research use only. We do not sell to patients.

YO-01027 Chemical Structure

YO-01027 Chemical Structure

CAS No. : 209984-56-5

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YO-01027 Related Antibodies

Top Publications Citing Use of Products

    YO-01027 purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2020 Feb 3;130(2):612-624.  [Abstract]

    Immunoblotting of the indicated proteins in CHO cells transfected with pBabe empty vector or pEGFRT790M/L858R and treated with vehicle (DMSO) or DBZ (250 nM) and/or gefitinib (1 μM). This is a representative image of two different experiments.

    YO-01027 purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2020 Feb 3;130(2):612-624.  [Abstract]

    Immunoblotting of the indicated proteins in PC9GR cells treated with vehicle (DMSO), DBZ (250 nM) or gefitinib (1 μM). This is a representative image of three different experiments.

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    Description

    YO-01027 (Dibenzazepine) (GMP) is YO-01027 (HY-13526) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. YO-01027 is a potent γ-secretase inhibitor[1][2].

    IC50 & Target

    IC50: 2.92±0.22 (Notch), 2.64±0.30 (APPL) nM[1]
    In Vitro

    YO-01027 (0.25-10 μM, during 1-18 days) promotes iPSC generation from human neonatal keratinocytes[2].
    YO-01027 (2 μM, 3 days) does not affect p53 activity in OCT4, SOX2-transduced human keratinocytes[2].
    YO-01027 (10 μM, 3 days) promotes the proliferation of supporting cells (SCs) in cultured mouse cochleae[3].
    YO-01027 (10 μM, 3 days) generates new hair cell (HCs) and increases the HCs number in neonatal mouse cochleae[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    YO-01027 Related Antibodies
    Molecular Weight

    463.48

    Formula

    C26H23F2N3O3
    CAS No.
    SMILES

    O=C(N[C@@H](C)C(N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C)C1=O)=O)CC4=CC(F)=CC(F)=C4
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    YO-01027 Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    YO-01027 (GMP)209984-56-5Dibenzazepine (GMP) DBZ (GMP)Notchγ-secretaseGamma secretaseCell therapydifferentiateiPSCkeratinocytesInhibitorinhibitorinhibit

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