2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. YY-23

YY-23 is a selective inhibitor of NMDAR (containing GluN2C or GluN2D). YY-23 inhibits GABAergic neurotransmission and enhances excitatory transmission by inhibiting NMDARs containing GluN2D on GABAergic interneurons in the prefrontal cortex. YY-23 has antidepressant activity and can be used for the research of neurological diseases.

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YY-23 Chemical Structure

YY-23 Chemical Structure

CAS No. : 1365029-75-9

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YY-23 Related Antibodies

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Description

YY-23 is a selective inhibitor of NMDAR (containing GluN2C or GluN2D). YY-23 inhibits GABAergic neurotransmission and enhances excitatory transmission by inhibiting NMDARs containing GluN2D on GABAergic interneurons in the prefrontal cortex. YY-23 has antidepressant activity and can be used for the research of neurological diseases[1].

IC50 & Target

NMDA Receptor

 

Molecular Weight

578.78

Formula

C33H54O8
CAS No.
SMILES

CC1=C(O[C@H]2C[C@@]3([H])[C@]4([H])CC[C@@]5(C[C@H](CC[C@@]5([C@@]4([H])CC[C@@]3([C@]21[H])C)C)O)[H])CC[C@@H](CO[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C
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Room temperature in continental US; may vary elsewhere.
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References
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YY-23 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YY-231365029-75-9YY23YY 23iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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