YZL-51N

Cat. No.: HY-159124: FAQs
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YZL-51N is a selective SIRT7 inhibitor with IC₅₀ value of 12.71 μM. YZL-51N disrupts SIRT7 enzyme activity by occupying the NAD⁺ binding pocket, thereby weakening DNA damage repair and inhibiting cancer cell survival. YZL-51N possesses anti-tumor activity and can be used in cancer research.

For research use only. We do not sell to patients.

YZL-51N Chemical Structure

CAS No. : 3031072-69-9

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

SIRT7

12.71 μM (IC₅₀)

In Vitro

YZL-51N (0-40 μM, 8 h) shows a dose-dependent increase in H3K18ac levels in HCT116 and HT29 cells ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	HCT116, HT29 and SW620
Concentration:	0-160 μM
Incubation Time:	48 h
Result:	Decreased cell proliferation in three colorectal cancer cell lines.

In Vivo

YZL-51N (15 mg/kg, subcutaneous injection) can reduce tumor volume in HCT116 xenograft model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

330.29

Formula

C₁₇H₁₄O₇

CAS No.

3031072-69-9

SMILES

O=C(OC)/C(C1=CC=C(O)C(O)=C1)=C\C(C2=CC=C(O)C(O)=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kang TS, et al. YZL-51N functions as a selective inhibitor of SIRT7 by NAD+ competition to impede DNA damage repair. iScience. 2024 May 16;27(6):110014. [Content Brief]

YZL-51N Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YZL-51N3031072-69-9SirtuinSIRT7 cellsHCT116 cellsHT29 cellsHCT116 xenograft mice modelAnticancer activityInhibitorinhibitorinhibit

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