2. Metabolic Enzyme/Protease
  3. Glucosidase
  4. (Z)-3-Butylidenephthalide

(Z)-3-Butylidenephthalide  (Synonyms: (Z)-Butylidenephthalide)

Cat. No.: HY-N0336A Purity: 99.59%
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(Z)-3-Butylidenephthalide is an antihyperglycemic agent by inhibiting the activity of intestinal and yeast R-glucosidases (IC50=2.35 mM; Ki=4.86 mM).

For research use only. We do not sell to patients.

(Z)-3-Butylidenephthalide Chemical Structure

(Z)-3-Butylidenephthalide Chemical Structure

CAS No. : 72917-31-8

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5 mg USD 400 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (Z)-3-Butylidenephthalide:

(Z)-3-Butylidenephthalide Related Antibodies

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Description

(Z)-3-Butylidenephthalide is an antihyperglycemic agent by inhibiting the activity of intestinal and yeast R-glucosidases (IC50=2.35 mM; Ki=4.86 mM)[1].

Cellular Effect
Cell Line Type Value Description References
CHO IC50
126.6 μM
Compound: 7
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation counting
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation counting
[PMID: 16643021]
HEK293 IC50
140.7 μM
Compound: 4j, Dehydroligustilide
Antagonist activity at rat recombinant TRPM8 overexpressed in HEK293 cells assessed as inhibition of icilin-induced intracellular calcium influx preincubated for 5 mins followed by icilin challenge by Fluo-4-AM dye-based spectrofluorimetric analysis
Antagonist activity at rat recombinant TRPM8 overexpressed in HEK293 cells assessed as inhibition of icilin-induced intracellular calcium influx preincubated for 5 mins followed by icilin challenge by Fluo-4-AM dye-based spectrofluorimetric analysis
[PMID: 23993334]
HEK293 IC50
153.3 μM
Compound: 4j, Dehydroligustilide
Antagonist activity at rat recombinant TRPM8 overexpressed in HEK293 cells assessed as inhibition of menthol-induced intracellular calcium influx preincubated for 5 mins followed by menthol challenge by Fluo-4-AM dye-based spectrofluorimetric analysis
Antagonist activity at rat recombinant TRPM8 overexpressed in HEK293 cells assessed as inhibition of menthol-induced intracellular calcium influx preincubated for 5 mins followed by menthol challenge by Fluo-4-AM dye-based spectrofluorimetric analysis
[PMID: 23993334]
HEK293 IC50
44.5 μM
Compound: 4j, Dehydroligustilide
Antagonist activity at rat recombinant TRPA1 overexpressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced intracellular calcium influx preincubated for 5 mins followed by allyl isothiocyanate challenge by Fluo-4-AM dye-based spectr
Antagonist activity at rat recombinant TRPA1 overexpressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced intracellular calcium influx preincubated for 5 mins followed by allyl isothiocyanate challenge by Fluo-4-AM dye-based spectr
[PMID: 23993334]
Molecular Weight

188.23

Formula

C12H12O2
CAS No.
Appearance

Liquid (Density: 1.204±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=C1O/C(C2=C1C=CC=C2)=C\CCC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 56.2 mg/mL (298.57 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.3126 mL 26.5632 mL 53.1265 mL
5 mM 1.0625 mL 5.3126 mL 10.6253 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.3126 mL 26.5632 mL 53.1265 mL 132.8162 mL
5 mM 1.0625 mL 5.3126 mL 10.6253 mL 26.5632 mL
10 mM 0.5313 mL 2.6563 mL 5.3126 mL 13.2816 mL
15 mM 0.3542 mL 1.7709 mL 3.5418 mL 8.8544 mL
20 mM 0.2656 mL 1.3282 mL 2.6563 mL 6.6408 mL
25 mM 0.2125 mL 1.0625 mL 2.1251 mL 5.3126 mL
30 mM 0.1771 mL 0.8854 mL 1.7709 mL 4.4272 mL
40 mM 0.1328 mL 0.6641 mL 1.3282 mL 3.3204 mL
50 mM 0.1063 mL 0.5313 mL 1.0625 mL 2.6563 mL
60 mM 0.0885 mL 0.4427 mL 0.8854 mL 2.2136 mL
80 mM 0.0664 mL 0.3320 mL 0.6641 mL 1.6602 mL
100 mM 0.0531 mL 0.2656 mL 0.5313 mL 1.3282 mL
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(Z)-3-Butylidenephthalide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Z)-3-Butylidenephthalide72917-31-8(Z)-ButylidenephthalideGlucosidaseAntihyperglycemicyeast R-glucosidaseLigusticum porteridiabeticInhibitorinhibitorinhibit

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