Z-Leu-Leu-Leu-fluoromethyl ketone (Synonyms: Z-LLL-FMK)

Cat. No.: HY-P5975: FAQs
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Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge.

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Z-Leu-Leu-Leu-fluoromethyl ketone Chemical Structure

CAS No. : 371167-61-2

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Description	Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge^[1]^[2].
IC₅₀ & Target	cysteine protease^[1].
Molecular Weight	507.64
Formula	C₂₇H₄₂FN₃O₅
CAS No.	371167-61-2
Sequence	Z-Leu-Leu-Leu-FMK
Sequence Shortening	Z-LLL-FMK
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (266 KB) Handling Instructions (2659 KB)
References	[1]. Simmons G, et al. Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11876-81. [Content Brief] [2]. Baig S, et al. Cysteine proteinase inhibitors in murine cysticercosis. Antimicrob Agents Chemother. 2006 Aug;50(8):2886-8. [Content Brief]

Z-Leu-Leu-Leu-fluoromethyl ketone Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z-Leu-Leu-Leu-fluoromethyl ketone371167-61-2Z-LLL-FMKCathepsinSARS-CoVSARS coronaviruscysteine proteaseSARS infectionInhibitorinhibitorinhibit

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Z-Leu-Leu-Leu-fluoromethyl ketone (Synonyms: Z-LLL-FMK)

Z-Leu-Leu-Leu-fluoromethyl ketone Related Antibodies

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Biological Activity

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References

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