Zaluzanin C 

Zaluzanin C is a sesquiterpene lactone. Zaluzanin C has anti-inflammatory activity and can inhibit the production of mtROS, block the NF-κB signaling pathway, and reduce the production of TNF-α. In addition, Zaluzanin C can inhibit the differentiation of 3T3-L1 preadipocytes into mature adipocytes^[1][2][3].

246.30

C₁₅H₁₈O₃

16838-87-2

C=C1[C@]2([H])[C@]3([H])[C@](CCC([C@]2([H])C[C@@H]1O)=C)([H])C(C(O3)=O)=C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Valkute TR, et al. Synthesis and anticancer studies of Michael adducts and Heck arylation products of sesquiterpene lactones, zaluzanin D and zaluzanin C from Vernonia arborea. RSC Adv. 2018 Nov 14;8(67):38289-38304.  [Content Brief]

  [2]. Kwak SH, et al. Zaluzanin C Inhibits Differentiation of 3T3-L1 Preadipocytes into Mature Adipocytes. J Obes Metab Syndr. 2019 Jun;28(2):105-111.  [Content Brief]

  [3]. Jung JW, et al. Zaluzanin C Alleviates Inflammation and Lipid Accumulation in Kupffer Cells and Hepatocytes by Regulating Mitochondrial ROS. Molecules. 2023 Nov 8;28(22):7484.  [Content Brief]