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  3. FKBP
  4. Zapalog

Zapalog is a photocleavable small-molecule heterodimerizer that can be used to repeatedly initiate, and instantaneously terminate, a physical interaction between two target proteins. Zapalog dimerizes any two proteins tagged with the FKBP and DHFR domains until exposure to light causes its photolysis.

For research use only. We do not sell to patients.

Zapalog Chemical Structure

Zapalog Chemical Structure

CAS No. : 1708091-24-0

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1 mg USD 650 In-stock
5 mg USD 1450 In-stock
10 mg USD 2300 In-stock
25 mg USD 4700 In-stock
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Based on 1 publication(s) in Google Scholar

Zapalog Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Zapalog

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Description

Zapalog is a photocleavable small-molecule heterodimerizer that can be used to repeatedly initiate, and instantaneously terminate, a physical interaction between two target proteins. Zapalog dimerizes any two proteins tagged with the FKBP and DHFR domains until exposure to light causes its photolysis[1].

IC50 & Target

FKBP, DHFR[1]
Molecular Weight

1108.24

Formula

C58H73N7O15
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C([C@H]1N(C(C(C(C)(C)CC)=O)=O)CCCC1)O[C@@H](C2=CC=CC(NC(CCCOC3=CC([N+]([O-])=O)=C(C(OCCOC4=C(OC)C=C(CC5=CN=C(N)N=C5N)C=C4OC)C)C=C3OC)=O)=C2)CCC6=CC=C(OC)C(OC)=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (90.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9023 mL 4.5117 mL 9.0233 mL
5 mM 0.1805 mL 0.9023 mL 1.8047 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9023 mL 4.5117 mL 9.0233 mL 22.5583 mL
5 mM 0.1805 mL 0.9023 mL 1.8047 mL 4.5117 mL
10 mM 0.0902 mL 0.4512 mL 0.9023 mL 2.2558 mL
15 mM 0.0602 mL 0.3008 mL 0.6016 mL 1.5039 mL
20 mM 0.0451 mL 0.2256 mL 0.4512 mL 1.1279 mL
25 mM 0.0361 mL 0.1805 mL 0.3609 mL 0.9023 mL
30 mM 0.0301 mL 0.1504 mL 0.3008 mL 0.7519 mL
40 mM 0.0226 mL 0.1128 mL 0.2256 mL 0.5640 mL
50 mM 0.0180 mL 0.0902 mL 0.1805 mL 0.4512 mL
60 mM 0.0150 mL 0.0752 mL 0.1504 mL 0.3760 mL
80 mM 0.0113 mL 0.0564 mL 0.1128 mL 0.2820 mL
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Zapalog Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zapalog1708091-24-0FKBPFK506-binding proteinInhibitorinhibitorinhibit

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