Zaragozic acid A trisodium (Synonyms: Squalestatin S1 trisodium)

Cat. No.: HY-116290A: FAQs
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Zaragozic acid A trisodium is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase.

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Zaragozic acid A trisodium Chemical Structure

CAS No. : 144541-82-2

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Other Forms of Zaragozic acid A trisodium:

Zaragozic acid A Get quote

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Description

Zaragozic acid A trisodium is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Hepatocyte	IC₅₀	39 nM Compound: 1	Inhibitory activity of compound was measured against cholesterol biosynthesis from [14C]- acetate by isolated rat hepatocytes Inhibitory activity of compound was measured against cholesterol biosynthesis from [14C]- acetate by isolated rat hepatocytes	10.1016/S0960-894X(01)80713-7

Molecular Weight

756.68

Formula

C₃₅H₄₃Na₃O₁₄

CAS No.

144541-82-2

SMILES

O=C([C@H]1O[C@](O2)(CCC([C@@H](OC(C)=O)[C@H](C)CC3=CC=CC=C3)=C)[C@H](O)[C@@H](OC(/C=C/[C@@H](C)C[C@@H](C)CC)=O)[C@]2(C(O[Na])=O)[C@]1(O)C(O[Na])=O)O[Na]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. J D Bergstrom, et al. Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):80-4. [Content Brief]

Zaragozic acid A trisodium Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zaragozic acid A trisodium144541-82-2Squalestatin S1 trisodiumOthersInhibitorinhibitorinhibit

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