2. GPCR/G Protein
  3. Adenylate Cyclase
  4. Zelminemab

Zelminemab  (Synonyms: AMG-301)

Cat. No.: HY-P99509 Purity: 98.79%
COA

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Zelminemab (AMG-301) is a humanized monoclonal antibody that inhibits PACAP type I (PAC1) receptor.

For research use only. We do not sell to patients.

CAS No. : 2225850-33-7

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1 mg USD 300 In-stock
5 mg USD 960 In-stock
10 mg USD 1630 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Zelminemab (AMG-301) is a humanized monoclonal antibody that inhibits PACAP type I (PAC1) receptor[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Humanized
In Vivo

Zelminemab (10 mg/kg; i.v.; once) reduces nociceptive neu-ronal activity in the TCC[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats, electricalstimulation was performed on the intact dura mater abovethe middle meningeal artery[2].
Dosage: 10 mg/kg
Administration: i.v.; once
Result: Induced an inhibition of stimulus-evoked nociceptive activity in the trigeminocervical com-plex (TCC).
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Zelminemab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation

Purity: 98.79%

COA (231 KB) SDS-PAGE (78 KB) SEC-HPLC (88 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Zelminemab Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zelminemab2225850-33-7AMG-301AMG301AMG 301Adenylate CyclaseAdenylyl cyclasePAC1human monoclonal antibodyInhibitorinhibitorinhibit

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