2. Metabolic Enzyme/Protease
  3. Factor Xa
  4. Zifaxaban

Zifaxaban is an orally active, competitively and selective Factor Xa (FXa) inhibitor with an IC50 of 11.1 nM for human FXa. Zifaxaban shows >10000-fold greater selectivity than other serine proteases. Zifaxaban can be used for the arterial and venous thrombosis research.

For research use only. We do not sell to patients.

Zifaxaban Chemical Structure

Zifaxaban Chemical Structure

CAS No. : 1378266-98-8

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Based on 1 publication(s) in Google Scholar

Zifaxaban Related Antibodies

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Description

Zifaxaban is an orally active, competitively and selective Factor Xa (FXa) inhibitor with an IC50 of 11.1 nM for human FXa. Zifaxaban shows >10000-fold greater selectivity than other serine proteases. Zifaxaban can be used for the arterial and venous thrombosis research[1].

IC50 & Target

IC50: 11.1 nM (human FXa)[1]
In Vivo

In venous thrombosis models in rats, Zifaxaban strongly suppresses thrombus formation with ED50 values of 3.09 mg/kg, and its best efficacy time occurred at 2 h after administration[1].
In arteriovenous-shunt thrombosis and carotid thrombosis models in rats, Zifaxaban inhibits thrombus formation in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

429.88

Formula

C20H16ClN3O4S
CAS No.
SMILES

O=C(C1=CC=C(Cl)S1)NC[C@H]2CN(C3=CC=C(N4C=CC=CC4=O)C=C3)C(O2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Zifaxaban Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zifaxaban1378266-98-8Factor XaFxaFXa inhibitoranticoagulantorally activearterialvenous thrombosisInhibitorinhibitorinhibit

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