2. Antibody-drug Conjugate/ADC Related Apoptosis
  3. Antibody-Drug Conjugates (ADCs) Apoptosis
  4. Zilovertamab vedotin

Zilovertamab vedotin  (Synonyms: VLS-101; MK-2140)

Cat. No.: HY-P99956 Purity: 98.61%
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Handling Instructions Technical Support

Zilovertamab vedotin (VLS-101) is a novel antibody-drug conjugate comprising the humanized monoclonal antibody zilovertamab and and the anti-microtubule cytotoxin monomethyl vedotin. Zilovertamab vedotin binding to tumor cell ROR1 results in rapid internalization, trafficking to lysosomes, antibody–agent conjugate cleavage, and monomethyl vedotin release. Zilovertamab vedotin induces apoptosis. Zilovertamab vedotin can be used in research of cancer.

For research use only. We do not sell to patients.

Zilovertamab vedotin Chemical Structure

Zilovertamab vedotin Chemical Structure

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Based on 1 publication(s) in Google Scholar

Zilovertamab vedotin Related Antibodies

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Description

Zilovertamab vedotin (VLS-101) is a novel antibody-drug conjugate comprising the humanized monoclonal antibody zilovertamab and and the anti-microtubule cytotoxin monomethyl vedotin. Zilovertamab vedotin binding to tumor cell ROR1 results in rapid internalization, trafficking to lysosomes, antibody–agent conjugate cleavage, and monomethyl vedotin release. Zilovertamab vedotin induces apoptosis. Zilovertamab vedotin can be used in research of cancer[1].

In Vitro

Zilovertamab vedotin (VLS-101; 0-100 μg/mL) induces cytotoxicity in ROR1+ primary MCL cells in a dose-dependent manner[1].
Zilovertamab vedotin (24h; ibrutinib-sensitive (JeKo-1) and resistant (JeKo BTK KD_2) cell lines) induces cell apoptosis and cell cycle arrest at G2/M[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Zilovertamab vedotin Related Antibodies
In Vivo

Zilovertamab vedotin (VLS-101; 2.5 mg/kg; i.v.; weekly, for 3 weeks) targets ROR1-expressing PDX models with dual resistance to ibrutinib and CAR T. A PDX model. Zilovertamab vedotin inhibits tumor growth[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NSG PDX mice models with dual resistance to ibrutinib and CAR T. A PDX model[1]
Dosage: 2.5 mg/kg
Administration: intravenous injection; weekly, for 3 weeks
Result: Eliminated subcutaneous tumor growth of BA-resistant PDX model (PDX-1).
Prolonged tumor bearing mouse survival.
Clinical Trial
Molecular Weight

151000 (average)

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Zilovertamab vedotin]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 98.61%

SDS (251 KB)

COA (231 KB) Others (111 KB) SEC-HPLC (97 KB)

Handling Instructions (2659 KB)
References
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Zilovertamab vedotin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zilovertamab vedotinVLS-101 MK-2140VLS101VLS 101MK2140MK 2140MK-2140Antibody-Drug Conjugates (ADCs)ApoptosisAntibody-Drug ConjugatesZilovertamabanti-microtubule cytotoxin monomethylcancerprimary MCL cellsInhibitorinhibitorinhibit

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