Zn(BQTC)

Cat. No.: HY-146287: FAQs
Data Sheet Handling Instructions

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Zn(BQTC) is a highly potent mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) inhibitor. Zn(BQTC) causes severe damage to the mtDNA and nDNA, sequentially disruptes mitochondrial and nuclear functions. Zn(BQTC) promotes the DNA damage-induced apoptotic signaling pathway. Zn(BQTC) has selectively antiproliferative activity against A549R cells. Zn(BQTC) can be used for researching anticancer.

For research use only. We do not sell to patients.

Zn(BQTC) Chemical Structure

CAS No. : 2785342-54-1

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Description

IC₅₀ & Target

IC₅₀: 10 nM in A549R cells^[1]

In Vitro

Zn(BQTC) (0-100 μM; 6 hours) exhibits highly and selectively antiproliferative activity against A549R with an IC₅₀ of 10 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	A549R, A549 and HL-7702^[1]
Concentration:	0-100 μM
Incubation Time:	6 hours
Result:	Exhibited potent antiproliferative activity against A549R and A549 cells with IC₅₀s of 10 nM and 11.59 μM, but low activity against HL-7702 with an IC₅₀ over 100 μM.

Molecular Weight

653.95

Formula

C₃₀H₃₉Cl₂N₅O₃Zn

CAS No.

2785342-54-1

SMILES

O=C([N]12[Zn+2]([NH]3CC2)([NH]4CC3)[NH](CC4)CC1)CCCCCCOC5=C(OC6=CC=CC=C76)C7=NC8=CC=CC=C58.[Cl-].[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang ZF, et al. Novel bifluorescent Zn(II)-cryptolepine-cyclen complexes trigger apoptosis induced by nuclear and mitochondrial DNA damage in cisplatin-resistant lung tumor cells [published online ahead of print, 2022 Apr 30]. Eur J Med Chem. 2022;238:114418. [Content Brief]

Zn(BQTC) Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zn(BQTC)2785342-54-1DNA/RNA SynthesisApoptosisAnticancerA549RMitochondrial functionNuclear functionInhibitorinhibitorinhibit

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