ZNL-0056

Cat. No.: HY-160564: FAQs
Data Sheet Handling Instructions

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ZNL-0056 is an orally active ATP-competitive inhibitor that targets both the Cys797 and Cys775 in the ATP binding site of EGFR. ZNL-0056 selectively inhibits EGFR and its downstream signaling in H3255 cells. ZNL-0056 can be used for the research of cancer.

For research use only. We do not sell to patients.

ZNL-0056 Chemical Structure

CAS No. : 2767987-38-0

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Biological Activity
Purity & Documentation
References
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Description

In Vivo

Pharmacokinetic Analysis in Male C57BL/6 Mice Model^[1]

Route	Dose (mg/kg)	T_1/2 (h)	T_max (h)	C_max (ng/mL)	AUC_last (ng·min/mL)	AUC_{INF_obs} (ng·min/mL)	AUC_%Extrap (ng·min/mL)	Cl_obs (mL·min/kg)	MRT_{INF_obs} (h)	F (%)
i.v.	1	0.33	0.08	965	21820	22013	0.86	53.6	0.30	/
i.p.	3	0.49	0.19	611	27398	27482	0.39	142.9	/	41.9
p.o.	10	3.8	0.14	658	53219	63341	15.7	158.8	/	24.4

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

477.58

Formula

C₂₅H₂₇N₅O₃S

CAS No.

2767987-38-0

SMILES

O=C(C1=CSC(NC(C=C)=O)=C1)NC2=NC3=CC=CC(C)=C3N2[C@H]4CN(CCCC4)C(C=C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li Z, et al. Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality. ACS Central Science. 2024.

ZNL-0056 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZNL-00562767987-38-0ZNL0056ZNL 0056EGFREpidermal growth factor receptorErbB-1HER1Cys797Cys775cancerEGFR Ba/F3H3255Inhibitorinhibitorinhibit

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