ZP 120C

Cat. No.: HY-106234: FAQs
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ZP 120C is a potent and partial ORL1 receptor agonist. ZP 120C inhibits electrically induced contraction. ZP 120C can be used in the research of hyponatremia/hypokalemia.

For research use only. We do not sell to patients.

ZP 120C Chemical Structure

CAS No. : 383123-18-0

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•Related Small Molecules:

•Related Proteins:

View All Opioid Receptor Isoform Specific Products:

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

Biological Activity
Purity & Documentation
References
Customer Review

Description

ZP 120C is a potent and partial ORL1 receptor agonist. ZP 120C inhibits electrically induced contraction. ZP 120C can be used in the research of hyponatremia/hypokalemia^[1]^[3].

IC₅₀ & Target^[1]

NOP Receptor/ORL1

In Vitro

ZP 120C (1 nM) inhibits electrically induced contraction of the mouse vas deferen^[2].
ZP 120C (1 μM) inhibits electrical field stimulation (EFS)-induced contractions in rat arteries^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ZP 120C (1 nM/kg/min, i.v., 2.5 h) displays an aquaretic effect in conscious, chronically instrumented rats with congestive heart failure (CHF)^[1]
. ZP 120C (1 nM, i.c.v., 30 min) produces pronociceptive effects in the tail withdrawal assay and decreases locomotor activity in mice^[2]
.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats induced by left coronary artery ligation (LCAL)^[1]
Dosage:	1 nM/kg/min
Administration:	Intravenous injection (i.v.), 2.5 h of constant intravenous infusion
Result:	Increased diuresis, free water clearance, fractional water excretion, and fractional distal water excretion.

Clinical Trial

Molecular Weight

1781.20

Formula

C₈₅HN₂₇O₁₅

CAS No.

383123-18-0

Sequence Shortening

Ac-RYYRWKKKKKKK-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hadrup N, et al. Opioid receptor-like 1 stimulation in the collecting duct induces aquaresis through vasopressin-independent aquaporin-2 downregulation. Am J Physiol Renal Physiol. 2004 Jul;287(1):F160-8. [Content Brief]

[2]. Rizzi A, et al. Pharmacological characterization of the novel nociceptin/orphanin FQ receptor ligand, ZP120: in vitro and in vivo studies in mice. Br J Pharmacol. 2002 Oct;137(3):369-74. [Content Brief]

[3]. Simonsen U, et al. ZP120 causes relaxation by pre-junctional inhibition of noradrenergic neurotransmission in rat mesenteric resistance arteries. Br J Pharmacol. 2008 Mar;153(6):1185-94. [Content Brief]

ZP 120C Related Classifications

Neurological Disease Cardiovascular Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZP 120C383123-18-0Opioid ReceptorContractionhyponatremiahypokalemiaaquaretictail withdrawal assayInhibitorinhibitorinhibit

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