2. Membrane Transporter/Ion Channel
  3. ATP Synthase
  4. ZW290

ZW290 is a compound to activate brown adipose tissue (BAT) thermogenic function. ZW290 increases the expression of uncoupling Protein 1 (UCP1) protein and inhibits ATP synthesis in BAT.

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ZW290 Chemical Structure

ZW290 Chemical Structure

CAS No. : 2411852-67-8

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Description

ZW290 is a compound to activate brown adipose tissue (BAT) thermogenic function. ZW290 increases the expression of uncoupling Protein 1 (UCP1) protein and inhibits ATP synthesis in BAT[1].

In Vitro

ZW290 in brown adipose tissue (BAT) induces nonshivering thermogenesis by limiting the oxidation of lipid droplet-derived fatty acids and increasing UCP1 protein levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ZW290 Related Antibodies
In Vivo

ZW290 (25-100 mg/kg; oral gavage; once a day; for 7 days) notably decreases the size of lipid droplets in BAT and increased the content of mitochondria and the expression of UCP1 in brown adipose tissue (BAT) and white adipose tissue (WAT). ZW290 could prolong the overall survival of mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Kunming (KM) mice (20 g) keeping under acute cold exposure (-20°C)[1]
Dosage: 25 mg/kg, 50 mg/kg, or 100 mg/kg
Administration: Oral gavage; once a day; for 7 days
Result: Notably decreased the size of lipid droplets in BAT and increased the content of mitochondria and the expression of UCP1 in BAT and WAT.
Molecular Weight

414.43

Formula

C20H18N2O6S
CAS No.
Appearance

Solid

Color

Yellow to brown

SMILES

O=C1N(C2=CC=C(C=C2)OC)C(N/C1=C\C3=CC(OC)=C(C=C3)OCC(O)=O)=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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ZW290 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZW2902411852-67-8ZW 290ZW-290ATP Synthasethermogenic functionATP synthesisUCP1 proteinoralInhibitorinhibitorinhibit

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