1. PROTAC Anti-infection
  2. PROTACs Dengue virus
  3. ZXH-8-004

ZXH-8-004 (2-12-2-deg) is a potent DENV E PROTAC degrader with an DC50 value of 0.21 µM. ZXH-8-004 shows exhibit antiviral potencies (Blue: E3 ligase (HY-103596), Black: linker (HY-42149); Pink: DENV E ligand (HY-161807)).

For research use only. We do not sell to patients.

ZXH-8-004 Chemical Structure

ZXH-8-004 Chemical Structure

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Description

ZXH-8-004 (2-12-2-deg) is a potent DENV E PROTAC degrader with an DC50 value of 0.21 µM. ZXH-8-004 shows exhibit antiviral potencies (Blue: E3 ligase (HY-103596), Black: linker (HY-42149); Pink: DENV E ligand (HY-161807))[1].

Molecular Weight

861.70

Formula

C38H33F6N7O10

SMILES

FC(F)(F)OC1=CC=C(NC2=CC=NC(NC3=CC=C(C(NCCOCCOCCOC4=C5C(C(N(C6CCC(NC6=O)=O)C5=O)=O)=CC=C4)=O)C=C3OC(F)(F)F)=N2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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ZXH-8-004 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
ZXH-8-004
Cat. No.:
HY-161806
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