ZYJ-25e

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ZYJ-25e is a potent histone deacetylase inhibitor (HDACi) with IC₅₀s of 0.047 μM and 0.139 μM for HDAC6 and HDAC8, respectively. ZYJ-25e is a tetrahydroisoquinoline-bearing hydroxamic acid analogue. ZYJ-25e shows marked antitumor potency in the MDA-MB231 xenograft model.

For research use only. We do not sell to patients.

ZYJ-25e Chemical Structure

CAS No. : 1287261-04-4

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View All Isoforms

HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

HDAC6

0.047 μM (IC₅₀)

HDAC8

0.139 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.94 μM Compound: 25e	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 21476600]
HeLa	IC₅₀	0.047 μM Compound: 25e	Inhibition of HDAC6 in human HeLa cell nuclear extract after 30 mins by fluorescence microplate reader Inhibition of HDAC6 in human HeLa cell nuclear extract after 30 mins by fluorescence microplate reader	[PMID: 21476600]
HeLa	IC₅₀	0.058 μM Compound: 25e	Inhibition of HDAC in human HeLa cell nuclear extract after 30 mins by fluorescence microplate reader Inhibition of HDAC in human HeLa cell nuclear extract after 30 mins by fluorescence microplate reader	[PMID: 21476600]
HeLa	IC₅₀	37.1 μM Compound: 25e	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 21476600]
HL-60	IC₅₀	47.6 μM Compound: 25e	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 21476600]
K562	IC₅₀	1.47 μM Compound: 25e	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 21476600]
MDA-MB-231	IC₅₀	0.79 μM Compound: 25e	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 21476600]
NB-4	IC₅₀	1.5 μM Compound: 25e	Cytotoxicity against human NB4 cells after 48 hrs by MTT assay Cytotoxicity against human NB4 cells after 48 hrs by MTT assay	[PMID: 21476600]

Molecular Weight

584.66

Formula

C₃₀H₄₀N₄O₈

CAS No.

1287261-04-4

SMILES

CC(C)(C)OC(N[C@@H]([C@@H](C)CC)C(N1[C@@H](CC2=CC=C(OCC(NO)=O)C=C2C1)C(NC3=CC=C(C=C3)OC)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yingjie Zhang, et al. Discovery of a tetrahydroisoquinoline-based hydroxamic acid derivative (ZYJ-34c) as histone deacetylase inhibitor with potent oral antitumor activities. J Med Chem. 2011 Aug 11;54(15):5532-9. [Content Brief]

ZYJ-25e Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZYJ-25e1287261-04-4HDACHistone deacetylasesTetrahydroisoquinolinehydroxamic acidMDA-MB231Inhibitorinhibitorinhibit

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