ZYJ-34c

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ZYJ-34c is an orally active and potent histone deacetylase inhibitor (HDACi) with IC₅₀s of 0.056 μM and 0.146 μM for HDAC6 and HDAC8, respectively. ZYJ-34c causes G1 phase arrest in low concentration. ZYJ-34c has antiproliferative activities. ZYJ-34c exhibits antitumor potency in MDA-MB-231 and HCT116 xenograft models and possesses antimetastatic potential in a mouse hepatoma-22 (H22) pulmonary metastasis model.

For research use only. We do not sell to patients.

ZYJ-34c Chemical Structure

CAS No. : 1314556-93-8

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

HDAC6

0.056 μM (IC₅₀)

HDAC8

0.146 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.77 μM Compound: 4, ZYJ-34c	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 21714538]
HeLa	IC₅₀	0.052 μM Compound: 4, ZYJ-34c	Inhibition of HDAC in human HeLa cell nuclear extracts using Boc-Lys (acetyl)-AMC as substrate after 30 mins by fluorescence assay Inhibition of HDAC in human HeLa cell nuclear extracts using Boc-Lys (acetyl)-AMC as substrate after 30 mins by fluorescence assay	[PMID: 21714538]
HeLa	IC₅₀	56.1 μM Compound: 4, ZYJ-34c	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 21714538]
HL-60	IC₅₀	65.8 μM Compound: 4, ZYJ-34c	Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay	[PMID: 21714538]
K562	IC₅₀	3.47 μM Compound: 4, ZYJ-34c	Antiproliferative activity against human K562 cells after 48 hrs by MTT assay Antiproliferative activity against human K562 cells after 48 hrs by MTT assay	[PMID: 21714538]
MCF7	IC₅₀	3.2 μM Compound: 4, ZYJ-34c	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 21714538]
MDA-MB-231	IC₅₀	0.58 μM Compound: 4, ZYJ-34c	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 21714538]
MDA-MB-231	IC₅₀	2.56 μM Compound: 1	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 28757101]
NB-4	IC₅₀	2.69 μM Compound: 4, ZYJ-34c	Antiproliferative activity against human NB4 cells after 48 hrs by MTT assay Antiproliferative activity against human NB4 cells after 48 hrs by MTT assay	[PMID: 21714538]
PC-3	IC₅₀	0.83 μM Compound: 4, ZYJ-34c	Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay	[PMID: 21714538]
U-266	IC₅₀	0.69 μM Compound: 1	Antiproliferative activity against human U266 cells after 48 hrs by MTT assay Antiproliferative activity against human U266 cells after 48 hrs by MTT assay	[PMID: 28757101]
U-937	IC₅₀	0.56 μM Compound: 1	Antiproliferative activity against human U937 cells after 48 hrs by MTT assay Antiproliferative activity against human U937 cells after 48 hrs by MTT assay	[PMID: 28757101]

Molecular Weight

582.69

Formula

C₃₁H₄₂N₄O₇

CAS No.

1314556-93-8

SMILES

CC(C)(C)CC(N[C@@H]([C@@H](C)CC)C(N1[C@@H](CC2=CC=C(OCC(NO)=O)C=C2C1)C(NC3=CC=C(C=C3)OC)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yingjie Zhang, et al. Discovery of a tetrahydroisoquinoline-based hydroxamic acid derivative (ZYJ-34c) as histone deacetylase inhibitor with potent oral antitumor activities. J Med Chem. 2011 Aug 11;54(15):5532-9. [Content Brief]

ZYJ-34c Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZYJ-34c1314556-93-8HDACHistone deacetylasesOrallyG1 phaseantiproliferativeMDA-MB-231HCT116hepatoma-22Inhibitorinhibitorinhibit

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