α-Glucosidase-IN-21

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α-Glucosidase-IN-21 (Compound 2B) is a potent, orally active α-glucosidase inhibitor with an IC₅₀ of 2.62 μM. α-Glucosidase-IN-21 shows anti-diabetic activity.

For research use only. We do not sell to patients.

α-Glucosidase-IN-21 Chemical Structure

CAS No. : 321686-01-5

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Description

α-Glucosidase-IN-21 (Compound 2B) is a potent, orally active α-glucosidase inhibitor with an IC₅₀ of 2.62 μM. α-Glucosidase-IN-21 shows anti-diabetic activity^[1].

In Vivo

α-Glucosidase-IN-21 (Compound 2B; 10 and 20 mg/kg; p.o.; daily, for 4 weeks) has anti-diabetic activity in Streptozocin (HY-13753)-induced diabetic rats^[1].
α-Glucosidase-IN-21 (10 and 20 mg/kg; p.o.; once) significantly decreases the serum glucose level after the administration of glucose (3 g/kg, oral) in rats^[1].
α-Glucosidase-IN-21 (2000 mg/kg; p.o.; daily, for 2 weeks) demonstrates no mortality in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar albino rats (170-200 g), Streptozotocin-induced diabetes model^[1]
Dosage:	10 and 20 mg/kg
Administration:	Oral administration; daily, for 4 weeks
Result:	Decreased the level of blood glucose, reversed Streptozocin-induced body weight loss. Showed antihyperlipidemic effects on Streptozotocin-induced diabetes, reduced to a significant level of serum biomarkers.

Molecular Weight

389.51

Formula

C₂₄H₂₃NO₂S

CAS No.

321686-01-5

SMILES

CC1=CC=C(C2=NC3=CC=CC=C3SC(C4=CC=C(OC)C(OC)=C4)C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mehmood R, et al. Synthesis of Novel 2, 3-Dihydro-1, 5-Benzothiazepines as α-Glucosidase Inhibitors: In Vitro, In Vivo, Kinetic, SAR, Molecular Docking, and QSAR Studies. ACS Omega, 2022 Aug 17.