2. Metabolic Enzyme/Protease
  3. Glucosidase
  4. α-Glucosidase-IN-23

α-Glucosidase-IN-23 is an orally active α-Glucosidase inhibitor. α-Glucosidase-IN-23 decreases blood glucose by a-glucosidase inhibition with an IC50 value of 4.48 μM. α-Glucosidase-IN-23 can be used for the research of diabetes.

For research use only. We do not sell to patients.

α-Glucosidase-IN-23 Chemical Structure

α-Glucosidase-IN-23 Chemical Structure

CAS No. : 161187-57-1

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α-Glucosidase-IN-23 Related Antibodies

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Description

α-Glucosidase-IN-23 is an orally active α-Glucosidase inhibitor. α-Glucosidase-IN-23 decreases blood glucose by a-glucosidase inhibition with an IC50 value of 4.48 μM. α-Glucosidase-IN-23 can be used for the research of diabetes[1].

IC50 & Target

IC50: 4.48 μM (a-glucosidase)[1].
In Vitro

α-Glucosidase-IN-23 (compound 8b) (1 μM) shows prominent antidiabetic effect[1].
α-Glucosidase-IN-23 diminishes ROS in β-cells and muscle cells[1].
α-Glucosidase-IN-23 decreases blood glucose by a-glucosidase inhibition with an IC50 value of 4.48 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-Glucosidase-IN-23 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: INS-1 Cells
Concentration: 1 μM
Incubation Time:
Result: Stimulated the growth of INS-1 cells in a dose-codependent approach.

Apoptosis Analysis[1]

Cell Line: INS-1 Cells
Concentration: 1 μM
Incubation Time:
Result: Restored the viability of INS-1 cells by about five times from apoptosis and eight times from necrosis.
In Vivo

α-Glucosidase-IN-23 (oral; 0.2 mmol/kg/day) only inhibits a-glucosidase in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 0.2 mmol/kg
Administration: Oral; 0.2 mmol/kg/day
Result:
Cmax (nmol/mL) Tmax (h) T1/2(h) AUC (ng/h/mL)
10.11 ± 1.17 0.8 ± 0.0 1.90 ± 1.04 36.7 ± 2.23
Molecular Weight

373.40

Formula

C20H23NO6
CAS No.
SMILES

CCOC(C1=C(NC(C)=C(C(OCC)=O)C1C2=C(OCO3)C3=CC=C2)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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α-Glucosidase-IN-23 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Glucosidase-IN-23161187-57-1Glucosidaseα-Glucosidaseblood glucosediabetesInhibitorinhibitorinhibit

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