1. Epigenetics Metabolic Enzyme/Protease
  2. Histone Demethylase Endogenous Metabolite
  3. α-Hydroxyglutaric acid

α-Hydroxyglutaric acid  (Synonyms: 2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid)

Cat. No.: HY-113038B Purity: ≥98.0%
COA Handling Instructions

α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.

For research use only. We do not sell to patients.

α-Hydroxyglutaric acid Chemical Structure

α-Hydroxyglutaric acid Chemical Structure

CAS No. : 2889-31-8

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Solvent
5mg (67.52 mM * 0.5mL in Ethanol) USD 98 In-stock
Solvent
10mg (67.52 mM * 1mL in Ethanol) USD 156 In-stock
Solvent
25mg (67.52 mM * 2.5mL in Ethanol) USD 325 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[1].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vitro

Isocitrate Dehydrogenase 1 (IDH1) and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and α-Hydroxyglutaric acid (2-Hydroxyglutarate), respectively[1].
α-Hydroxyglutaric acid (2-Hydroxyglutarate) inhibits the activity of multiple histone demethylases. α-Hydroxyglutaric acid occupies the same space as α-KG does in the active site of histone demethylases. α-Hydroxyglutaric acid (2-Hydroxyglutarate) inhibits the activity of TET 5-methylcytosine hydroxylases[1].
Treatment of U-87MG cells with α-Hydroxyglutaric acid (2-Hydroxyglutarate; 10-50 mM) increases HIF-1α and decreases endostatin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

148.11

Formula

C5H8O5

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(O)C(O)CCC(O)=O

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Solution, -20°C, 2 years

Purity & Documentation

Purity: ≥99.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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α-Hydroxyglutaric acid
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