2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. α-MSH TFA

α-MSH TFA  (Synonyms: α-Melanocyte-Stimulating Hormone TFA)

Cat. No.: HY-P0252A Purity: 98.79%
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α-MSH (α-Melanocyte-Stimulating Hormone) TFA, an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH TFA is a post-translational derivative of pro-opiomelanocortin (POMC).

For research use only. We do not sell to patients.

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α-MSH TFA Chemical Structure

α-MSH TFA Chemical Structure

CAS No. : 171869-93-5

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Based on 14 publication(s) in Google Scholar

Other Forms of α-MSH TFA:

α-MSH TFA Related Antibodies

Top Publications Citing Use of Products

View All Melanocortin Receptor Isoform Specific Products:

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MC1R MC3R MC2R MC4R MC5R

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Description

α-MSH (α-Melanocyte-Stimulating Hormone) TFA, an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH TFA is a post-translational derivative of pro-opiomelanocortin (POMC)[1][2].

IC50 & Target

MC4R

 

In Vitro

α-MSH TFA modulates CNS inflammation by acting directly on melanocortin receptors in glial cells. α-MSH TFA modulates NFκB activation. α-MSH TFA inhibits translocation of transcription factor κB to the nucleus[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-MSH TFA Related Antibodies
In Vivo

α-MSH TFA (50 μg/0.2 ml saline; i.p.) given systemically effectively modulates inflammatory reactions[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Formula

C77H109N21O19S.xC2HF3O2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Sequence Shortening

Ac-SYSMEHFRWGKPV-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (Need ultrasonic)

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References
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α-MSH TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-MSH171869-93-5α-Melanocyte-Stimulating HormoneMelanocortin ReceptorMC ReceptorendogenousneuropeptideantipyreticMC4RInhibitorinhibitorinhibit

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