2. Neuronal Signaling
  3. α-synuclein
  4. α-Synuclein 4554W

α-Synuclein 4554W is an inhibitor of α-Synuclein (aSyn) aggregation with associated toxicity. α-Synuclein 4554W consists of GIVNGVKA sequences, previously identified through intracellular library screening. α-Synuclein 4554W reduces fibril formation of aSyn mutants assocaited with Parkinson’s disease.

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Custom Peptide Synthesis

α-Synuclein 4554W Chemical Structure

α-Synuclein 4554W Chemical Structure

CAS No. : 2243207-00-1

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α-Synuclein 4554W Related Antibodies

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Description

α-Synuclein 4554W is an inhibitor of α-Synuclein (aSyn) aggregation with associated toxicity. α-Synuclein 4554W consists of GIVNGVKA sequences, previously identified through intracellular library screening. α-Synuclein 4554W reduces fibril formation of aSyn mutants assocaited with Parkinson’s disease[1].

Molecular Weight

1041.20

Formula

C45H80N14O14
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ac-Lys-Asp-Gly-Ile-Val-Asn-Gly-Val-Lys-Ala-NH2
Sequence Shortening

Ac-KDGIVNGVKA-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (48.02 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9604 mL 4.8022 mL 9.6043 mL
5 mM 0.1921 mL 0.9604 mL 1.9209 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.9604 mL 4.8022 mL 9.6043 mL 24.0108 mL
5 mM 0.1921 mL 0.9604 mL 1.9209 mL 4.8022 mL
10 mM 0.0960 mL 0.4802 mL 0.9604 mL 2.4011 mL
15 mM 0.0640 mL 0.3201 mL 0.6403 mL 1.6007 mL
20 mM 0.0480 mL 0.2401 mL 0.4802 mL 1.2005 mL
25 mM 0.0384 mL 0.1921 mL 0.3842 mL 0.9604 mL
30 mM 0.0320 mL 0.1601 mL 0.3201 mL 0.8004 mL
40 mM 0.0240 mL 0.1201 mL 0.2401 mL 0.6003 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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α-Synuclein 4554W Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Synuclein 4554W2243207-00-1α-synucleinα-SynaSyn aggregationfibril formationaSyn mutantsParkinson’s diseaseInhibitorinhibitorinhibit

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