α-Synuclein inhibitor 8 

α-Synuclein inhibitor 8 is an active inhibitor of α-Synuclein with an IC₅₀ value of 2.5 µM. α-Synuclein inhibitor 8 has highly inhibition on the aggregation and disaggregation of α-Synuclein fibers. α-Synuclein inhibitor 8 reduces the formation of inclusions in neurons that can repairs damage neurons and improves Parkinson’s disease (PD)-like symptoms. α-Synuclein inhibitor 8 has high antioxidant activity and low cytotoxicity^[1].

IC50: 2.5 µM^[1]

α-Synuclein inhibitor 8 (Compound 2ee) (0-100 μM; 0-96 h) inhibits the aggregation of α-Synuclein in a dose-dependent manner^[1].
α-Synuclein inhibitor 8 (100 µM; 48 h) decomposes mature fiber into soluble protein and a small amount of short insoluble fiber^[1].
α-Synuclein inhibitor 8 (1-1000 µM; 0.5 h or 24 h) increases the clearance rate of reactive oxygen species in a dose-dependent manner. α-Synuclein inhibitor 8 has low cytotoxicity to H4 and SH-SY5Y cells (cell viability is higher than 80%)^[1].
α-Synuclein inhibitor 8 (10 µM; 38 h) has inhibitory effect on α-Synuclein aggregation and inclusion body formation in H4 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-Synuclein inhibitor 8 (Compound 2ee) (0.9 μg/μL; i.v.; single dose) significantly improves Parkinson’s disease (PD)-like symptoms such as weak grip, limb stiffness and poor balance in C57 mice model of PD. α-Synuclein inhibitor 8 has neuroprotective effect on the middle caudate putamen (CPU) and substantia nigra reticular (SNr) of the brain in C57 mice model of PD^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

432.43

C₂₄H₂₀N₂O₆

2883627-64-1

OC1=CC=C(O)C=C1/C=C/C(NC2=CC=C(NC(/C=C/C3=CC(O)=CC=C3O)=O)C=C2)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lü MH, et al. Hybrids of polyphenolic/quinone acids, the potential preventive and therapeutic drugs for PD: Disaggregate α-Syn fibrils, inhibit inclusions, and repair damaged neurons in mice. Eur J Med Chem. 2023 Jan 18;249:115122.  [Content Brief]